Patient Information

Biofilms don't become resistant to disrupters since they can't develop resistance genes like bacteria which are alive. However disrupter choice isn't just an issue of what biofilm the pathogen makes (eDNA or amyloid fiber - some make both), but your genetics. Twenty percent of the general population world wide have one of four genetic mutations/deletions that result in either too much fibrin being produced (Factor II or V mutations) or difficulty activating plasminogen to make plasmin which breaks down fibrin (PAI-1 4G deletion or elevated lipoprotein(a)). Seventy percent of my chronic UTI/IC patients had at least one of these and some even multiple ones. Due to the extra fibrin, patients with these genetics have extensive biofilms making antibiotics 10 to 1,000 times less effective and often results in multi-drug resistance with the survival of exposed but not eradicated bacteria. The accumulation of fibrin due to genetics has to be addressed as well identifying what contribution various pathogens make to biofilm production. LabCorp has put together a custom panel #505443 (not on website but can be ordered through the Link system) to test for all of these genetics as well as measuring how much fibrin you may be producing due to other causes (tick-borne, mold toxins, auto-immunity, high homocysteine, etc.). Knowing that information also helps determine what your body needs to stop biofilm production. Wish there was a one size fits all but the disrupters needed will change based on pathogens found. The ones for your genetics will stay the same to "normalize" the fibrin/fibrinolysis balance and prevent future infections from becoming chronic.

An increase in D-dimer (a degradation product of fibrin) will indicate that a fibrinolytic like lumbrokinase is working on the biofilms. Additional pathogens will also surface out of the biofilm in greater quantities so the MicroGenDX test can find them and antibiotics can reach them. This testing is needed since many pathogens that have been embedded don't grow well on standard urine culture plates (anaerobes, slow growing ones, and cell wall deficient bacteria). Cultures also report as contaminated if they find healthy lactobacilli (they show up to acidify the urine and discourage the growth of higher pH loving pathogens) or any fungal growth (can also be released from biofilms). Many pathogens also make their own biofilms and once we identify what those pathogens are, will add in specific disrupters for those types. Selection of antibiotics is aimed at the major pathogens. Exposing low percentage ones to an antibiotic only creates more drug resistance since only a sub-therapeutic will have reached the bacteria still embedded. This isn't a one and done. It can take multiple rounds of testing and treatment to get to the bottom of infections that have been multiplying inside of biofilms for months or years. That being said, we are seeing many patients who have struggled for decades become and stay infection free once the biofilms are addressed properly based on your genetics for fibrin production, keeping your vitamin D above 50, and clearing excess ammonia which damages the bladder wall, stabilizes biofilms, and raises the pH. I am happy to discuss the various pieces needed with your provider: https://ruthkriz.intakeq.com/booking This does work but there is more involved than just addressing biofilms.