Patient Information

Biofilms don't become resistant to disrupters since they can't develop resistance genes like bacteria which are alive. However disrupter choice isn't just an issue of what biofilm the pathogen makes (eDNA or amyloid fiber - some make both), but your genetics. Twenty percent of the general population world wide have one of four genetic mutations/deletions that result in either too much fibrin being produced (Factor II or V mutations) or difficulty activating plasminogen to make plasmin which breaks down fibrin (PAI-1 4G deletion or elevated lipoprotein(a)). Seventy percent of my chronic UTI/IC patients had at least one of these and some even multiple ones. Due to the extra fibrin, patients with these genetics have extensive biofilms making antibiotics 10 to 1,000 times less effective and often results in multi-drug resistance with the survival of exposed but not eradicated bacteria. The accumulation of fibrin due to genetics has to be addressed as well identifying what contribution various pathogens make to biofilm production. LabCorp has put together a custom panel #505443 (not on website but can be ordered through the Link system) to test for all of these genetics as well as measuring how much fibrin you may be producing due to other causes (tick-borne, mold toxins, auto-immunity, high homocysteine, etc.). Knowing that information also helps determine what your body needs to stop biofilm production. Wish there was a one size fits all but the disrupters needed will change based on pathogens found. The ones for your genetics will stay the same to "normalize" the fibrin/fibrinolysis balance and prevent future infections from becoming chronic.