Ruth Kriz, APRN 3-2025
What you need to know while you are taking lumbrokinase:
This is a fibrinolytic enzyme. It dissolves something called fibrin, which is a part of the normal
clotting process in the blood. You are taking this because you have been either making too
much or not breaking it down efficiently.
Excess fibrin contributes to increased cardiovascular disease risk and to biofilm production,
resulting in chronic infections. Taking a fibrinolytic helps your body normalize fibrinolysis. This is
needed when you have excess fibrin triggered by genetics, infection, or inflammation. If
however, there is an increased need for clotting, like minor surgeries or traumas, this
supplement needs to be temporarily stopped to allow adequate clotting and healing.
Please remember that to be effective lumbrokinase must be taken on an empty stomach (at
least 30 minutes after liquids other than water, 1 hour after dairy, or 2 hours after solids). Do
not take with any other medications or supplements and do not consume anything but water
for 30 minutes afterwards.
Here are the guidelines you should follow:
1. Do not take nonsteroidal anti-inflammatory drugs [NSAIDs], while taking Bolouke. These
include ibuprofen, Aleve, aspirin, and many prescription NSAID drugs. They may cause
bleeding. Lumbrokinase will never trigger bleeding but it can slow the clotting process.
Tylenol is safe.
2. Stop lumbrokinase one week prior to any surgical procedure and wait two weeks before
restarting it. This includes dental surgery-including deep gum cleanings, colonoscopywhere there may or may not be biopsies or polyp removals, and any surgical incision.
3. Stop lumbrokinase if you have a significant trauma [motor vehicle accident for example]
and wait two weeks before restarting. If you are unclear, please contact your practitioner.
4. If you need to go to the emergency room, please advise them you are on an oral
fibrinolytic enzyme to normalize your clotting. [That’s the sentence you should say].
That way they can more accurately interpret any blood work you have done.
5. If you have questions or need further explanation, please contact your practitioner’s
office.